ICCAS OpenIR
Synthesis and properties of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers
Chen, WN; Yang, J; Wang, SG; Bei, JZ
2002-10-01
Source PublicationACTA POLYMERICA SINICA
ISSN1000-3304
Issue5Pages:695-698
AbstractA series of multiblock copolymers of PLLA-PEG(PLE) with high molecular weight were synthesized by coupling PLLA-PEG-PLLA triblock copolymers with succinic anhydride in the presence of (N,N-dimethylamino) pyridine(DMAP) and dicyclohexylcarbodimide (DCC). The results of the viscometry measurement, GPC and H-1-MR, elucidated that multiblock PLE copolymers with high content of short PEG segments (Mn= 2000) had been successfully obtained. The crystallinity of the copolymers was investigated by X-ray diffraction. Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation. In a word, the measurements showed that the multiblock PLE copolymers had high content of short PEG segments (M-n = 2000), high molecular weight (M-w similar to 100,000), excellent hydrophilicity and mechanical properties. The results of cells cultured on the multiblock PLE copolymer indicated that it might be suitable to be utilized as cell scaffold for tissue engineering.
KeywordPoly(L-lactide) Poly(Ethylene Glycol) Multiblock Copolymer Cell Scaffold
Indexed BySCI
Language英语
WOS IDWOS:000178936800030
PublisherSCIENCE CHINA PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79262
Collection中国科学院化学研究所
Corresponding AuthorChen, WN
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Chen, WN,Yang, J,Wang, SG,et al. Synthesis and properties of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers[J]. ACTA POLYMERICA SINICA,2002(5):695-698.
APA Chen, WN,Yang, J,Wang, SG,&Bei, JZ.(2002).Synthesis and properties of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers.ACTA POLYMERICA SINICA(5),695-698.
MLA Chen, WN,et al."Synthesis and properties of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers".ACTA POLYMERICA SINICA .5(2002):695-698.
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