ICCAS OpenIR
The chemical resolution of racemic cis-2-hydroxymethyl-5(cytosine-1 '-yl)-1,3-oxathiolane (BCH-189)-one direct method to obtain lamivudine as anti-HIV and anti-HBV agent
Li, JZ; Gao, LX; Ding, MX
2002
Source PublicationSYNTHETIC COMMUNICATIONS
ISSN0039-7911
Volume32Issue:15Pages:2355-2359
AbstractRacemic cis-BCH-189 can be resolved to (-)-enantiomer (lamivudine) and (+)-enantiomer by esterification of cis-2-hydroxymethyl-5-(N-4(')-acetylcytosine-1'-yl)-1,3-oxathiolane and (+)-menthyl chloroformate in CH3CN with pyridine as base. The two diastereomers of ester were seperated by recrystallization in methanol at 0degreesC. Lamivudine was obtained by deprotection of (-)-diastereomer with high yield.
DOI10.1081/SCC-120006006
Indexed ByIC ; CCR ; SCI
Language英语
WOS IDWOS:000177370100012
PublisherMARCEL DEKKER INC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/79096
Collection中国科学院化学研究所
Corresponding AuthorLi, JZ
Recommended Citation
GB/T 7714
Li, JZ,Gao, LX,Ding, MX. The chemical resolution of racemic cis-2-hydroxymethyl-5(cytosine-1 '-yl)-1,3-oxathiolane (BCH-189)-one direct method to obtain lamivudine as anti-HIV and anti-HBV agent[J]. SYNTHETIC COMMUNICATIONS,2002,32(15):2355-2359.
APA Li, JZ,Gao, LX,&Ding, MX.(2002).The chemical resolution of racemic cis-2-hydroxymethyl-5(cytosine-1 '-yl)-1,3-oxathiolane (BCH-189)-one direct method to obtain lamivudine as anti-HIV and anti-HBV agent.SYNTHETIC COMMUNICATIONS,32(15),2355-2359.
MLA Li, JZ,et al."The chemical resolution of racemic cis-2-hydroxymethyl-5(cytosine-1 '-yl)-1,3-oxathiolane (BCH-189)-one direct method to obtain lamivudine as anti-HIV and anti-HBV agent".SYNTHETIC COMMUNICATIONS 32.15(2002):2355-2359.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, JZ]'s Articles
[Gao, LX]'s Articles
[Ding, MX]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, JZ]'s Articles
[Gao, LX]'s Articles
[Ding, MX]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, JZ]'s Articles
[Gao, LX]'s Articles
[Ding, MX]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.