ICCAS OpenIR
Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen
Wang, MX; Zhao, SM
2002-09-09
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume43Issue:37Pages:6617-6620
AbstractCatalyzed by Rhodococcus sp. AJ270 microbial cells under mild conditions, a range of racemic 2-aryl-4-pentenenitriles 1 underwent effective hydrolysis to afford excellent yields of enantiomerically pure (R)-(-)-2-aryl-4-pentenamides 2 and (S)-(+)-2-aryl-4-pentenoic acids 3 in most cases. The application of this biotransformation has been shown by a two-step synthesis of (R)-(-)-baclcfen. (C) 2002 Elsevier Science Ltd. All rights reserved.
KeywordBiotransformations Nitrile Hydratase Amidase Chemoenzymatic Synthesis (r)-(-)-baclofen
Indexed ByIC ; CCR ; SCI
Language英语
WOS IDWOS:000177659700031
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78996
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, MX,Zhao, SM. Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen[J]. TETRAHEDRON LETTERS,2002,43(37):6617-6620.
APA Wang, MX,&Zhao, SM.(2002).Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen.TETRAHEDRON LETTERS,43(37),6617-6620.
MLA Wang, MX,et al."Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen".TETRAHEDRON LETTERS 43.37(2002):6617-6620.
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