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Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)
Shi, GX; Cai, Q; Wang, CY; Lu, N; Wang, SG; Bei, JZ
2002-03-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume13Issue:3-4Pages:227-232
AbstractIn this paper, poly(L-lactic acid) (PLLA) and poly(L-lactic-co-glycolic acid) (PLGA) were synthesized, and the biocompatibility of PLGA(50/50) (molar ratio) was evaluated by observing the tissue response during implanting PLGA(50/50) into rats. After the PLGA(50/50) was implanted into rats for 12 weeks, the lymphocytes and plasma cells became small or disappeared at the muscle tissue of implant site which indicates the biocompatibility of PLGA(50/50) is very good. A series of porous cell scaffolds of PLGA and PLLA were prepared by using a solution-casting/salt-leaching, technique. An improved method in which a density bottle instead of a graduated cylinder was developed to measure their porosities. It was found that the accuracy and reproducibility of the improved method for measuring porosity are excellent. A porous PLGA(50/50) scaffold alas used to study chondrocytes culture. The chondrocytes were proliferated in porous PLGA(50/50) scaffold and the composite cell/PLGA was successfully obtained for cartilage regeneration. Copyright (C) 2002 John Wiley Sons, Ltd.
KeywordPoly(L-lactic Acid) Poly(L-lactic-co-glycolic Acid) Biocompatibility Porous Cell Scaffold Cell Culture
DOI10.1002/pat.178
Indexed ByISTP ; SCI
Language英语
WOS IDWOS:000174200300013
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78926
Collection中国科学院化学研究所
Corresponding AuthorBei, JZ
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
3.China PLA Gen Hosp, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Shi, GX,Cai, Q,Wang, CY,et al. Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(3-4):227-232.
APA Shi, GX,Cai, Q,Wang, CY,Lu, N,Wang, SG,&Bei, JZ.(2002).Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid).POLYMERS FOR ADVANCED TECHNOLOGIES,13(3-4),227-232.
MLA Shi, GX,et al."Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)".POLYMERS FOR ADVANCED TECHNOLOGIES 13.3-4(2002):227-232.
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