ICCAS OpenIR
Hydrolysis of phospholipid and possible mechanism of gallstone formation
Xu, YZ; Somjen, G; Yang, ZL; Weng, SF; Liu, HW; Li, WH; Zhang, X; Wu, JG; Xu, DF
2002-04-01
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume60Issue:4Pages:711-714
AbstractTaurocholic salt-phospholipid-cholesterol-water solubilized systems were used to investigate the physical/chemical behavior of bile. Phase separation that produces float and precipitation was observed in the system. Analysis using FT-IR spectroscopy and GC-MS methods showed that aliphatic acids were principal component of the float. This demonstrated that hydrolysis of phospholipid must have occurred in the system. Considering that phospholipid plays a very important role in solubilizing cholesterol in bile, whereas aliphatic acids can not solubilize cholesterol, we suggest that the hydrolysis of phospholipid may be related to the formation of gallstone.
KeywordFt-ir Phospholipid Cholesterol Gallstone
Indexed BySCI
Language英语
WOS IDWOS:000175079300029
PublisherSCIENCE CHINA PRESS
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78902
Collection中国科学院化学研究所
Corresponding AuthorXu, YZ
Affiliation1.Peking Univ, Dept Chem, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xu, YZ,Somjen, G,Yang, ZL,et al. Hydrolysis of phospholipid and possible mechanism of gallstone formation[J]. ACTA CHIMICA SINICA,2002,60(4):711-714.
APA Xu, YZ.,Somjen, G.,Yang, ZL.,Weng, SF.,Liu, HW.,...&Xu, DF.(2002).Hydrolysis of phospholipid and possible mechanism of gallstone formation.ACTA CHIMICA SINICA,60(4),711-714.
MLA Xu, YZ,et al."Hydrolysis of phospholipid and possible mechanism of gallstone formation".ACTA CHIMICA SINICA 60.4(2002):711-714.
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