ICCAS OpenIR
Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone
Cai, Q; Bei, JZ; Wang, SG
2002-02-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume13Issue:2Pages:105-111
AbstractA series of copolylactones was synthesized by ring-opening copolymerization of glycolide, L-lactide and epsilon-caprolactone, using stannous octoate as catalyst. The in vitro degradation behaviors of them were studied and data demonstrated different degradation rates which mainly depended on the compositions. Investigation of the 5-fluorouracil (5-Fu) release from these copolylactones revealed that the composition, degradation rate and the morphology of the polymeric matrix played an important role on the drug release kinetics. A sustained 5-Fu release without initial time lag was obtained from random poly(lactide-co-glycolide-co-caprolactone) (r-PGLC) drug carrier, and it differed from the cases of polylactide (PLA) or random poly(lactide-co-glycolide) (PLGA), which usually showed an initial time lag or biphasic drug release behavior. It was due to the low, glass transition temperature (T-g) of the r-PGLC and the drug would diffuse faster in rubbery state under the experimental temperature. Furthermore, a significant change in the drug release behavior of r-PGLC was observed when the temperatures were changed around the T-g of the drug carrier, which implied that the drug release behavior could be regulated by adjusting the morphology of the drug carrier. Copyright (C) 2002 John Wiley Sons, Ltd.
KeywordPoly(Lactide-co-glycolide-co-caprolactone) (R-pglc) Poly(Lactide-co-glycolide) (Plga) Drug Release Behavior Degradation Morphology
Indexed BySCI
Language英语
WOS IDWOS:000173655700004
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78854
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Bei, JZ,Wang, SG. Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(2):105-111.
APA Cai, Q,Bei, JZ,&Wang, SG.(2002).Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone.POLYMERS FOR ADVANCED TECHNOLOGIES,13(2),105-111.
MLA Cai, Q,et al."Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone".POLYMERS FOR ADVANCED TECHNOLOGIES 13.2(2002):105-111.
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