ICCAS OpenIR
A novel approach to enantiopure cyclopropane compounds from biotransformation of nitriles
Wang, MX; Feng, GQ
2002-11-01
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume26Issue:11Pages:1575-1583
AbstractRhodococcus sp. AJ270, a powerful and versatile nitrile hydratase/amidase containing microbial whole-cell system, catalyzed the enantioselective hydrolysis of both racemic trans- and cis-2-arylcyclopropanecarbonitriles to afford the corresponding amides and acids with enantiomeric excesses as high as > 99%. The reaction rate and enantioselectivity observed for both nitrile hydratase and amidase were also strongly dependent upon the nature of the substituent and substitution pattern on the benzene ring of the substrates. The application of and the advantages of biotransformation of nitriles were demonstrated by preparing (1S,2R)-2-phenylcyclopropylamine and (1R,2R)-2-phenylcyclopropylmethylamine through facile and straightforward chemical manipulations of (1S,2S)-2-phenyleyclopropanecarboxylic acid and (1R,2R)-2-phenylcyclopropanecarboxamide, respectively.
DOI10.1039/b200110a
Indexed BySCI ; IC
Language英语
WOS IDWOS:000179559300011
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78694
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, MX,Feng, GQ. A novel approach to enantiopure cyclopropane compounds from biotransformation of nitriles[J]. NEW JOURNAL OF CHEMISTRY,2002,26(11):1575-1583.
APA Wang, MX,&Feng, GQ.(2002).A novel approach to enantiopure cyclopropane compounds from biotransformation of nitriles.NEW JOURNAL OF CHEMISTRY,26(11),1575-1583.
MLA Wang, MX,et al."A novel approach to enantiopure cyclopropane compounds from biotransformation of nitriles".NEW JOURNAL OF CHEMISTRY 26.11(2002):1575-1583.
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