ICCAS OpenIR
Effect of amino acid on forming residue-residue contacts in proteins
Jiang, ZT; Zhang, LX; Chen, J; Xia, A; Zhao, D
2002-10-01
Source PublicationPOLYMER
ISSN0032-3861
Volume43Issue:22Pages:6037-6047
AbstractThe long-range contacts contribute more function to the protein folding and play an active role in the stability of protein molecules. In this paper, we calculated the number of short- and long-range contacts from 278 globular proteins and analyzed the effects of amino acids on the long-range contacts by contrasting the average number of the long-range contacts between different amino acid residues in the protein sample. The amino acids of Leu, Val, Ile, Met, Phe, Tyr, Cys, and Tip are easy to form the long-range contacts, and the average number of long-range contacts per residue is 5.008 when R-c = 0.80 nm. Here R-c is the minimum distance between two C-alpha atoms of residues. The amino acids of Glu, Gln, Asp, Asn, Lys, Ser, Arg, and Pro are difficult to form the long-range contacts, and the average number of long-range contacts per residue is only 3.232 when R-c = 0.80 nm. However, the effect of amino acid on the short-range contact is negligible, and the average number of short-range contacts per residue ranges from 3.649 to 3.721 when R-c = 0.80 nm. We also find that the highest preference is observed for Cys-Cys contact, and the lowest preference is Gln-His contact. The average number of contacts depends on R-c and two cases of R-c = 0.65 and 0.80 nm are discussed. The average distance of the residue-residue contacts is also concluded. Through these calculations, we can discuss how the amino acids affect the protein folding and how the proteins achieve the stability conformations. (C) 2002 Published by Elsevier Science Ltd.
KeywordAmino Acid Short-range And Long-range Contacts Protein Folding
Indexed BySCI
Language英语
WOS IDWOS:000178269200027
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78472
Collection中国科学院化学研究所
Corresponding AuthorZhang, LX
Affiliation1.Zhejiang Univ, Dept Phys, Hangzhou 310028, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Polymer Phys Lab, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Jiang, ZT,Zhang, LX,Chen, J,et al. Effect of amino acid on forming residue-residue contacts in proteins[J]. POLYMER,2002,43(22):6037-6047.
APA Jiang, ZT,Zhang, LX,Chen, J,Xia, A,&Zhao, D.(2002).Effect of amino acid on forming residue-residue contacts in proteins.POLYMER,43(22),6037-6047.
MLA Jiang, ZT,et al."Effect of amino acid on forming residue-residue contacts in proteins".POLYMER 43.22(2002):6037-6047.
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