ICCAS OpenIR
Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids
Wang, MX; Liu, CS; Li, JS
2002-01-21
Source PublicationTETRAHEDRON-ASYMMETRY
ISSN0957-4166
Volume12Issue:24Pages:3367-3373
AbstractThe enantioselective hydrolysis of 3-alkyl- and 3-arylglutaronitriles catalyzed by Rhodococcus sp. AJ270 cells, afforded the corresponding (S)-3-substituted 4-cyanobutanoic acids with low to moderate enantiomeric purities. Additives such as acetone were found to significantly enhance the enantioselectivity of the desymmetrization, giving enantiomeric excesses of up to 95%. The synthetic potential of the homochiral product was also demonstrated by the preparation of optically active (R)- and (S)-4-amino-3-phenylbutanoic acids. (C) 2002 Elsevier Science Ltd. All rights reserved.
Indexed BySCI ; IC
Language英语
WOS IDWOS:000174682700006
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78450
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, MX,Liu, CS,Li, JS. Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids[J]. TETRAHEDRON-ASYMMETRY,2002,12(24):3367-3373.
APA Wang, MX,Liu, CS,&Li, JS.(2002).Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids.TETRAHEDRON-ASYMMETRY,12(24),3367-3373.
MLA Wang, MX,et al."Enzymatic desymmetrization of 3-alkyl- and 3-arylglutaronitriles, a simple and convenient approach to optically active 4-amino-3-phenylbutanoic acids".TETRAHEDRON-ASYMMETRY 12.24(2002):3367-3373.
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