ICCAS OpenIR
Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography
Yang, GL; Li, ZW; Wang, DX; Zhang, ZF; Liu, ED; Chen, Y
2002-10-01
Source PublicationCHROMATOGRAPHIA
ISSN0009-5893
Volume56Issue:7-8Pages:515-518
AbstractA high-performance liquid chromatographic method was developed for the chiral separation of a new anti-diabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, and its L-enantiomer. The separation was performed on a Sumichiral OA-3300 column. Optimized mobile phase was 0.025 mol.L-1 ammonium acetate in methanol solution. UV detection was at 210 nm. Baseline chiral separation was obtained within 12 minutes. The detection limits are 80 pg for the D-enantiomer and 120 pg for the L-enantiomer. RSD of the method was below 1% (n = 5).
KeywordColumn Liquid Chromatography Chiral Separation N-(Trans-4-isopropylcyclohexylcarbonyl)-d L-phenylalanine Isomers
Indexed BySCI
Language英语
WOS IDWOS:000178836600019
PublisherVIEWEG
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78422
Collection中国科学院化学研究所
Corresponding AuthorYang, GL
Affiliation1.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
2.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yang, GL,Li, ZW,Wang, DX,et al. Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography[J]. CHROMATOGRAPHIA,2002,56(7-8):515-518.
APA Yang, GL,Li, ZW,Wang, DX,Zhang, ZF,Liu, ED,&Chen, Y.(2002).Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography.CHROMATOGRAPHIA,56(7-8),515-518.
MLA Yang, GL,et al."Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography".CHROMATOGRAPHIA 56.7-8(2002):515-518.
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