Spectroscopic investigation on the telomeric DNA base sequence repeat
Xu, SC; Al, XC; Sun, ZY; Zhang, QY; Zhang, XK
AbstractTelomeres are protein-DNA complexes at the terminals of linear chromosomes, which protect chromosomal integrity and maintain cellular replicative capacity. From single-cell organisms to advanced animals and plants, structures and functions of telomeres are both very conservative. In cells of human and vertebral animals, telomeric DNA base sequences all are (TTAGGG). In the present work, we have obtained absorption and fluorescence spectra measured from seven synthesized oligonucleotides to simulate the telomeric DNA system and calculated their relative fluorescence quantum yields on which not only telomeric DNA characteristics are predicted but also possibly the shortened telomeric sequences during cell division are implied. Oligonucleotide 5'- TTAGGGTTAGGG holds a low relative fluorescence quantum yield and remarkable excitation energy innerconversion, which tallies with the telomeric sequence of (TTAGGG). This result shows that telomeric DNA has a strong non-radiative or innerconvertible, capability.
KeywordDna Telomere Oligonucleotide Fluorescence Quantum Yield
Indexed BySCI
WOS IDWOS:000174261900006
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Document Type期刊论文
Corresponding AuthorXu, SC
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xu, SC,Al, XC,Sun, ZY,et al. Spectroscopic investigation on the telomeric DNA base sequence repeat[J]. CHINESE SCIENCE BULLETIN,2002,47(2):108-111.
APA Xu, SC,Al, XC,Sun, ZY,Zhang, QY,&Zhang, XK.(2002).Spectroscopic investigation on the telomeric DNA base sequence repeat.CHINESE SCIENCE BULLETIN,47(2),108-111.
MLA Xu, SC,et al."Spectroscopic investigation on the telomeric DNA base sequence repeat".CHINESE SCIENCE BULLETIN 47.2(2002):108-111.
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