ICCAS OpenIR
Two-photon excitation studies of hypocrellins for photodynamic therapy
Liu, J; Zhao, YW; Zhao, JQ; Xia, AD; Jiang, LJ; Wu, S; Ma, L; Dong, YQ
2002-11-01
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume68Issue:2-3Pages:156-164
AbstractThe photophysical and photochemical properties of hypocrellins (HA and HB) are examined with two-photon excitations at 800 nm using femtosecond pulses from a Ti:sapphire laser. The two-photon excited fluorescence spectra of HA and HB are very similar to those obtained by one-photon excitation, which may indicate that the two-photon induced photodynamic processes of hypocrellins are similar to one-photon induced photodynamic processes. The two-photon excitation cross sections of HA and HB are measured at 800 nm as about 34.8 X 10(-5)0 cm(4) s /photon and 21.3 X 10(-50) cm(4) s/photon, respectively. The large two-photon cross sections of both HA and HB, suggest that the hypocrellins can be potential two-photon phototherapeutic agents. As an example for two-photon photodynamic therapy of hypocrellins, we also further examine the cell-damaging effects of HA upon two-photon illumination. Our preliminary results of cell viability test indicate hypocrellins can effectively damage the Hela cells under two-photon illumination. (C) 2002 Elsevier Science B.V. All rights reserved.
KeywordHypocrellins Photosensitization Two-photon Phototherapy Dynamics (Tppdt) Two-photon Cross Section Hela Cell
Indexed BySCI
Language英语
WOS IDWOS:000179892100013
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:67[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78192
Collection中国科学院化学研究所
Corresponding AuthorXia, AD
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
3.Univ Sci & Technol China, Dept Biol, Hefei 230026, Peoples R China
Recommended Citation
GB/T 7714
Liu, J,Zhao, YW,Zhao, JQ,et al. Two-photon excitation studies of hypocrellins for photodynamic therapy[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2002,68(2-3):156-164.
APA Liu, J.,Zhao, YW.,Zhao, JQ.,Xia, AD.,Jiang, LJ.,...&Dong, YQ.(2002).Two-photon excitation studies of hypocrellins for photodynamic therapy.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,68(2-3),156-164.
MLA Liu, J,et al."Two-photon excitation studies of hypocrellins for photodynamic therapy".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 68.2-3(2002):156-164.
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