ICCAS OpenIR
The comparative analysis of the energies of conjugated triple base triplets and their applications
Liu, SQ; Yang, J; Bai, CL; Liu, CQ
2002-02-14
Source PublicationJOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
ISSN0166-1280
Volume578Pages:215-219
AbstractWe built 64 sets of 3D models of DNA triplex base triplets (TBT) and minimized their energies. The TBTs were divided into 32 pairs of conjugated ones on the basis of their sequence characteristic, and the energies of each pair of them were compared and analyzed, the results showed: (i) The duplex DNA of which any strand contains at least a couple of A or T, has a preference for selecting the oligodeoxyribonucleic acid (ODN) strand containing abundant T to form TBT. (ii) The duplex DNA of which any strand contains at least a couple of G or C has a preference for selecting ODN containing abundant G to form symmetric antiparallel TBT, but selecting ODN containing abundant C to form asymmetric parallel TBT. (iii) The duplex DNA of which any strand contains only one of A, T, G or C has a preference for selecting ODN containing abundant pyrimidines (T or C) to form antiparallel TBT. Additionally, two examples of TBTs applications, in designing ODN to form triplex with duplex were presented. The energy calculation result revealed that 15-TCG is the best ligand of the HIV PPT duplex. The comparative analysis of energies of the conjugated TBTs provides directive significance for designing ODN strand that is easy to form triplex in theory. (C) 2002 Elsevier Science B.V. All rights reserved.
KeywordConjugated Tbt Energy Comparative Analysis Applications
Indexed BySCI
Language英语
WOS IDWOS:000173617200026
PublisherELSEVIER SCIENCE BV
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78096
Collection中国科学院化学研究所
Corresponding AuthorLiu, CQ
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100081, Peoples R China
3.Yunnan Univ, Modern Biol Ctr, Kunming 650091, Peoples R China
Recommended Citation
GB/T 7714
Liu, SQ,Yang, J,Bai, CL,et al. The comparative analysis of the energies of conjugated triple base triplets and their applications[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2002,578:215-219.
APA Liu, SQ,Yang, J,Bai, CL,&Liu, CQ.(2002).The comparative analysis of the energies of conjugated triple base triplets and their applications.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,578,215-219.
MLA Liu, SQ,et al."The comparative analysis of the energies of conjugated triple base triplets and their applications".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 578(2002):215-219.
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