ICCAS OpenIR
Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide
Wang, SG; Hou, JW; Bei, JZ; Zhao, YQ
2001-08-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume44Issue:4Pages:419-426
AbstractThe biodegradation rate and biocompatibility of poly(d, l-lactide) (PDLLA) in vivo were evaluated. The aim of this study was to establish a nerve guide constructed by the PDLLA with 3-D microenvironment and to repair a 10 mm of sciatic nerve gap in rats. The process of the nerve regeneration was investigated by histological assessment, electrophysiological examination, and determination of wet weight recovery rate of the gastrocnemius muscle. After 3 weeks, the nerve guide had changed from a transparent to an opaque status. The conduit was degraded and absorbed partly and had lost their strength with breakage at the 9th week of postoperation. At the conclusion of 12 weeks, proximal and distal end of nerves were anastomosed by nerve regeneration and the conduit vanished completely. The results suggest that PDLLA conduits may serve for peripheral nerve regeneration and PDLLA is a sort of hopeful candidate for tissue engineering.
KeywordNerve Conduit Nerve Guiding Regeneration Biodegradation Biocompatibility Tissue Engineering Poly(d L-lactide)
Indexed BySCI
Language英语
WOS IDWOS:000171890600011
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/78044
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Peoples Hosp Henan Prov, Zhengzhou 450003, Peoples R China
Recommended Citation
GB/T 7714
Wang, SG,Hou, JW,Bei, JZ,et al. Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2001,44(4):419-426.
APA Wang, SG,Hou, JW,Bei, JZ,&Zhao, YQ.(2001).Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide.SCIENCE IN CHINA SERIES B-CHEMISTRY,44(4),419-426.
MLA Wang, SG,et al."Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide".SCIENCE IN CHINA SERIES B-CHEMISTRY 44.4(2001):419-426.
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