ICCAS OpenIR
Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical
Ma, JH; Zhao, JQ; Jiang, LJ
2001-08-30
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume61Issue:3Pages:122-128
AbstractIn order to improve the photo sensitizing activity of HB further, the complex of 5,8-di-Br-HB with Al3+ was first designed and synthesized in high yield. 5,8-di-Br-HB forms a 2:1 type (metal-ligand ratio) complex with Al3+ measured by molar ratio and continuous variation methods. The new photosensitizer was characterized by UV-Vis, IR, H-1 NMR and elemental analysis measurements. Based on the above experimental results, we first proposed a polymer-like structural model of the complex. The water-solubility and red absorption of the [Al-2(5,8-di-Br-HB)Cl-4](n) complex are both enhanced over hypocrellin B. In addition, the EPR and spectrophotometric measurements demonstrate that semiquinone anion radical of [Al-2(5,8-di-Br-HB)Cl-4](n) can be produced by [Al,(5,8-di-Br-HB)Cl-4], photosensitization. The generation efficiency of {[Al-2(5,8-di-Br-HB)Cl-4](n)}(.-) is almost equal to that of HB.-. These results obtained indicated that [Al-2(5,8-di-Br-HB)Cl-4](n) was at least a favorable Type I photo therapeutic agent. (C) 2001 Published by Elsevier Science B.V.
KeywordPhotodynamic Therapy Semiquinone Anion Radical Electron Paramagnetic Resonance Aluminium Ion-complexed 5 8-di-br-hb
Indexed BySCI
Language英语
WOS IDWOS:000171085500005
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77928
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Ma, JH,Zhao, JQ,Jiang, LJ. Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2001,61(3):122-128.
APA Ma, JH,Zhao, JQ,&Jiang, LJ.(2001).Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,61(3),122-128.
MLA Ma, JH,et al."Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 61.3(2001):122-128.
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