ICCAS OpenIR
Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro
Xu, SJ; Chen, S; Zhang, MH; Shen, T; Liu, ZW; Zhao, YP; Wu, YD
2001-12-01
Source PublicationANTI-CANCER DRUG DESIGN
ISSN0266-9536
Volume16Issue:6Pages:271-277
Abstract2-Cyclohexylamino-2-demethoxy-hypocrellin B (CHAHB) is a new photosensitizer synthesized by the mild reaction between hypocrellin B (HB) and cyclohexylamine, in which the perihydroxylated perylenequinone structure of the parent HB is preserved and the photoresponse is enhanced markedly. Electron paramagnetic resonance (EPR) spin trapping measurements and 9,10-diphenylanthracene (DPA) bleaching studies were employed to investigate the photodynamic action of CHAHB in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(.-)) generated by illuminating CHAHB in aerobic solution have been observed. Compared with HB, CHAHB distinctly enhanced the O-2(.-)-generating abilities, although O-1(2)-generating abilities were lowered. The photodynamic action of CHAHB in the therapy of cancer was investigated in vitro. The results in vitro revealed a much more significant decrease in cancer cell growth than with HB. Laser or dye alone had no effect, indicating that intratumor CHAHB and laser therapy may prove useful in unresectable cancer.
KeywordElectron Paramagnetic Resonance Hypocrellin Photodynamic Therapy Singlet Oxygen Superoxide Anion Radical
Indexed BySCI
Language英语
WOS IDWOS:000178032500002
PublisherOXFORD UNIV PRESS
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77746
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Chinese Acad Med Sci, PUMC Hosp, Dept Surg, Beijing 100730, Peoples R China
3.PUMC, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Xu, SJ,Chen, S,Zhang, MH,et al. Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro[J]. ANTI-CANCER DRUG DESIGN,2001,16(6):271-277.
APA Xu, SJ.,Chen, S.,Zhang, MH.,Shen, T.,Liu, ZW.,...&Wu, YD.(2001).Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro.ANTI-CANCER DRUG DESIGN,16(6),271-277.
MLA Xu, SJ,et al."Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro".ANTI-CANCER DRUG DESIGN 16.6(2001):271-277.
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