ICCAS OpenIR
Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer
Wang, SG; Chen, HL; Cai, Q; Bei, JZ
2001-03-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume12Issue:3-4Pages:253-258
AbstractThe in vitro degradation behavior of the polyester/polyether copolymer based on polycaprolactone/poly(ethylene oxide)/polylactide (PCEL) significantly depends on the caproxyl (CL)/lactyl (LA) ratio for the same poly(ethylene oxide) (PEO) content. The PCEL copolymer with rich CL units shows the crystalline structure of PCL with a slow degradation rate while it presents crystalline structure of poly-L-lactide (PLLA) with more LA units that has a fast degradation rate. In the case of PCEL with similar CL and LA unit contents, it only exhibits the crystalline structure of PEO and the degradation rate is faster especially during the early stage of the degradation due to the rapid cleavage of the PEG. The drug release system is prepared using 5-fluorouracil (5-Fu) as the model drug and PCEL copolymers as the drug carriers. It is shown that the drug release rate is controlled by the composition, morphology and properties of the PCEL copolymer. In particular, the PCEL copolymer with 70% LA units displays a near zero-order sustained release in about 60 days. Therefore these copolymers have potential application as a controlled 5-fluorouracil delivery system. Copyright (C) 2001 John Wiley & Sons, Ltd.
KeywordPolycaproloctone/poly(Ethylene Oxide)/polylactide Tri-component Copolymer Crystallinity Degradation Drug Controlled Release 5-fluorouracil
Indexed BySCI
Language英语
WOS IDWOS:000167190800014
PublisherJOHN WILEY & SONS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77728
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, SG,Chen, HL,Cai, Q,et al. Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2001,12(3-4):253-258.
APA Wang, SG,Chen, HL,Cai, Q,&Bei, JZ.(2001).Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer.POLYMERS FOR ADVANCED TECHNOLOGIES,12(3-4),253-258.
MLA Wang, SG,et al."Degradation and 5-fluorouracil release behavior in vitro of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymer".POLYMERS FOR ADVANCED TECHNOLOGIES 12.3-4(2001):253-258.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, SG]'s Articles
[Chen, HL]'s Articles
[Cai, Q]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, SG]'s Articles
[Chen, HL]'s Articles
[Cai, Q]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, SG]'s Articles
[Chen, HL]'s Articles
[Cai, Q]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.