ICCAS OpenIR
The aluminium(III) complex of hypocrellin B as a PDT photosensitizer
Ma, JH; Zhao, JQ; Jiang, LJ
2001
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume25Issue:6Pages:847-852
AbstractThe complex of hypocrellin B (HB) with aluminium was synthesized to improve the water solubility and red absorption of the parent pigment. The complexation of HB with Al3+ resulted in the formation of a complex with 1:1 Al(iii):HB stoichiometry (Al3+-HB) measured by molar ratio and continuous variation methods, respectively. The structure of this complex has been characterized by UV-Vis, IR, H-1 NMR and elemental analysis data. Compared with HB, the complex possesses excellent solubility in water; in addition, the absorption wavelength of Al3+-HB shifts bathochromically into the phototherapeutic window (600-900 nm). The generation of active oxygen species, including the superoxide radical anion (O-2(.-)) and singlet oxygen (O-1(2)), by Al3+-HB photosensitization was observed. The efficiency of O-2(.-) generation by Al3+-HB was twice as much as that of HB. Under our experimental conditions, the rate of O-2(.-) generation by Al3+-HB was about 2.3 muM min(-1) measured by the cytochrome c reduction method using 578 nm light. The quantum yield of singlet oxygen (O-1(2)) was 0.23 in DMSO determined by the 9,10-DPA (diphenylanthracene) photobleaching experiments. These results suggest that the new complex possesses an enhanced type I process but a decreased type II process as compared with hypocrellin B.
Indexed BySCI
Language英语
WOS IDWOS:000168993600014
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77672
Collection中国科学院化学研究所
Corresponding AuthorZhao, JQ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Ma, JH,Zhao, JQ,Jiang, LJ. The aluminium(III) complex of hypocrellin B as a PDT photosensitizer[J]. NEW JOURNAL OF CHEMISTRY,2001,25(6):847-852.
APA Ma, JH,Zhao, JQ,&Jiang, LJ.(2001).The aluminium(III) complex of hypocrellin B as a PDT photosensitizer.NEW JOURNAL OF CHEMISTRY,25(6),847-852.
MLA Ma, JH,et al."The aluminium(III) complex of hypocrellin B as a PDT photosensitizer".NEW JOURNAL OF CHEMISTRY 25.6(2001):847-852.
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