ICCAS OpenIR
Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate
Tian, CH; Xu, SJ; Chen, S; Shen, JQ; Zhang, MH; Shen, T
2001
Source PublicationFREE RADICAL RESEARCH
ISSN1071-5762
Volume35Issue:5Pages:543-554
AbstractHypocrellin B (HB), a perylenequinone derivative, is an efficient phototherapeutic agent. The chelation of HB with Zinc ions (Zn2+) results in a metal chelate (Zn-HB) which exhibits considerable absorption (lambda (max) = 612 nm) in the phototherapeutic window. The structure of this chelate has been characterized by U-V-Vis, IR and mass spectra. The redox potentials of the Zn-HB chelate were E-ox = + 1.1V (vs. SCE) and E-re = -0.7V (vs. SCE) as measured using the circle volt curve. The quantum yield of singlet oxygen generated by the Zn-HB chelate was 0.86, which both the electron spin trap (EPR) method and the chemical trap method show to be about 0.1 higher than that of its parent compound HB. In irradiated oxygen-saturated solutions of Zn-HB chelate, superoxide radical anions and hydroxyl radicals were detected by EPR spectroscopy using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent.
KeywordHypocrellin b Zinc Ion Chelate Electron Paramagnetic Resonance Photodynamic Activity Singlet Oxygen
Indexed BySCI
Language英语
WOS IDWOS:000172596600009
PublisherHARWOOD ACAD PUBL GMBH, TAYLOR & FRANCIS GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77650
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Tian, CH,Xu, SJ,Chen, S,et al. Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate[J]. FREE RADICAL RESEARCH,2001,35(5):543-554.
APA Tian, CH,Xu, SJ,Chen, S,Shen, JQ,Zhang, MH,&Shen, T.(2001).Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate.FREE RADICAL RESEARCH,35(5),543-554.
MLA Tian, CH,et al."Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate".FREE RADICAL RESEARCH 35.5(2001):543-554.
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