ICCAS OpenIR
Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor
Xiu, GH; Jiang, L; Li, P
2001-07-05
Source PublicationBIOTECHNOLOGY AND BIOENGINEERING
ISSN0006-3592
Volume74Issue:1Pages:29-39
AbstractA mathematical model has been developed for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor in which the enzyme-catalyzed reaction (the irreversible uni-uni competitive Michaelis-Menten kinetics is chosen as an example) was coupled with intraparticle diffusion, external mass transfer, and axial dispersion. The effects of mass-transfer limitations, competitive inhibition of substrates, deactivation on the enzyme effective enantioselectivity, and the optical purity and yield of the desired product are examined quantitatively over a wide range of parameters using the orthogonal collocation method. For a first-order reaction, an analytical solution is derived from the mathematical model for slab-, cylindrical-, and spherical-enzyme supports. Based on the analytical solution for the steady-state resolution process, a new concise formulation is presented to predict quantitatively the mass-transfer limitations on enzyme effective enantioselectivity and optical purity and yield of the desired product for a continuous steady-state kinetic resolution process in a fixed-bed reactor. (C) 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 74: 29-39, 2001.
KeywordImmobilized Enzyme Kinetic Resolution Mass-transfer Limitations Fixed-bed Reactor Analytical Solution Orthogonal Collocation Method
Indexed BySCI
Language英语
WOS IDWOS:000169219900004
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77472
Collection中国科学院化学研究所
Corresponding AuthorXiu, GH
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Shenyang Inst Chem Technol, Dept Chem Engn, Shenyang, Peoples R China
Recommended Citation
GB/T 7714
Xiu, GH,Jiang, L,Li, P. Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor[J]. BIOTECHNOLOGY AND BIOENGINEERING,2001,74(1):29-39.
APA Xiu, GH,Jiang, L,&Li, P.(2001).Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor.BIOTECHNOLOGY AND BIOENGINEERING,74(1),29-39.
MLA Xiu, GH,et al."Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor".BIOTECHNOLOGY AND BIOENGINEERING 74.1(2001):29-39.
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