ICCAS OpenIR
Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer
Wang, TY; Liu, HL; Chen, JR; Liu, FG; Gu, Y; Ma, JS
2001-08-06
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume11Issue:15Pages:2049-2052
AbstractThe synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (DPCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibits photodynamic activity in terms of type I and type II mechanisms under irradiation. The quantum yield of O-1(2) in CHCl3 is 0.7. For the photocytotoxicity to tumor cells, DPCOH proved to be 200 times more potent than HPD, and the dark toxicity is low (dark IC90 > 32 mug/mL). (C) 2001 Elsevier Science Ltd. All rights reserved.
Indexed BySCI
Language英语
WOS IDWOS:000169982200020
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77340
Collection中国科学院化学研究所
Corresponding AuthorMa, JS
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Gen Hosp PLA, Beijing 100853, Peoples R China
3.Chinese Acad Sci, Inst Photog Chem, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, TY,Liu, HL,Chen, JR,et al. Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2001,11(15):2049-2052.
APA Wang, TY,Liu, HL,Chen, JR,Liu, FG,Gu, Y,&Ma, JS.(2001).Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,11(15),2049-2052.
MLA Wang, TY,et al."Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 11.15(2001):2049-2052.
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