ICCAS OpenIR
Biodegradation behaviour of poly(lactide-co-glycolide) induced by microorganisms
Cai, Q; Bei, JZ; Luo, AQ; Wang, SG
2001
Source PublicationPOLYMER DEGRADATION AND STABILITY
ISSN0141-3910
Volume71Issue:2Pages:243-251
AbstractThe effect of microorganisms on degradation of PLLA was compared by using different kind of fungus in vitro. Fusarium L023 showed the strongest activity in accelerating the degradation of PLLA. Therefore, the in vitro degradation of PLGA copolymers was examined by immersing PLGA(50/50) and PLGA(70/30) films in media with or without Fusarium L023. Degradation of the polymeric films was monitored by measuring inherent viscosity and weight loss, as well as using techniques such as GPC, H-1 NMR, DSC and SEM. In this case, the degradation of PLGA copolymers could be markedly accelerated by Fusarium L023. The microorganism assimilated the released oligomers as carbon-source, and this could explain why the inherent viscosity decreased more slowly for inoculated samples at the later stage than those in the controlled medium. Moreover, the Fusarium L023 would favor the degradation of PLGA copolymers by destroying the crystallization of PLLA segments at the later stage, which was caused by the preferential loss of glycotyl unit in the case of hydrolysis, for Fusarium L023 was more effective on accelerating the degradation of PLLA than PGA. (C) 2001 Elsevier Science Ltd. All rights reserved.
KeywordPoly(Lactide-co-glycolide) Biodegradation Micro Organism Fungi
Indexed BySCI
Language英语
WOS IDWOS:000166656400006
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/77106
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Bei, JZ,Luo, AQ,et al. Biodegradation behaviour of poly(lactide-co-glycolide) induced by microorganisms[J]. POLYMER DEGRADATION AND STABILITY,2001,71(2):243-251.
APA Cai, Q,Bei, JZ,Luo, AQ,&Wang, SG.(2001).Biodegradation behaviour of poly(lactide-co-glycolide) induced by microorganisms.POLYMER DEGRADATION AND STABILITY,71(2),243-251.
MLA Cai, Q,et al."Biodegradation behaviour of poly(lactide-co-glycolide) induced by microorganisms".POLYMER DEGRADATION AND STABILITY 71.2(2001):243-251.
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