DNA biosensor with high sensitivity amplified by gold nanoparticles
Zhao, HQ; Lin, L; Li, JR; Tang, JA; Duan, MX; Jiang, L
AbstractA biosensor based on quartz crystal microbalance (QCM) using 50 nm gold nanoparticles as the amplification probe for DNA detection was reported in this paper. It had been found that a DNA detection sensitivity of 10(-14) M could be obtained, which was higher than what has been ever reported using the same method. In the curve of weight increase (Deltam) against the target DNA in solution, a plateau appeared as the concentration of analyte DNA increasing, implying the existence of monolayer of gold nanoparticles binding on the top of target DNA. The high sensitivity was explained not only by the weight of the larger particles, but also the larger area occupied by the larger particles which need less target DNA for their binding.
KeywordGold Nanoparticles Dna Sensor Quartz Crystal Microbalance (Qcm) Amplification
Indexed BySCI
WOS IDWOS:000173729600009
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Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorJiang, L
Affiliation1.Chinese Acad Sci, Inst Chem, Colloid & Interface Lab Mol Ctr, Beijing 100101, Peoples R China
2.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Zhao, HQ,Lin, L,Li, JR,et al. DNA biosensor with high sensitivity amplified by gold nanoparticles[J]. JOURNAL OF NANOPARTICLE RESEARCH,2001,3(4):321-323.
APA Zhao, HQ,Lin, L,Li, JR,Tang, JA,Duan, MX,&Jiang, L.(2001).DNA biosensor with high sensitivity amplified by gold nanoparticles.JOURNAL OF NANOPARTICLE RESEARCH,3(4),321-323.
MLA Zhao, HQ,et al."DNA biosensor with high sensitivity amplified by gold nanoparticles".JOURNAL OF NANOPARTICLE RESEARCH 3.4(2001):321-323.
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