ICCAS OpenIR
Capillary electrophoresis of aromatic acids in urine - Applied to the diagnosis of phenylketonuria
Guo, Q; Chang, LW; Chen, Y
2001-09-01
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume29Issue:9Pages:1000-1002
AbstractMicro-aromatic acids play an important role in the diagnosis of organic acidurias. In this study, a simple and rapid capillary electrophoresis ( CE) method for the analysis of micro-aromatic acids in urine had been developed, the electrophoretic behaviour of these aromatic acids had been discussed in detail. The electrophoresis was carried out in a 70 cm long, 50 mum ID fused-silica capillary, filled with 25 mmol/L borax buffer (pH = 10.0) containing 25 mmol/L sodium cholate as the electroosmotic flow modifier at a protential of 16 kV. The detection was at 214 mn. Under this condition, five phenylketonuria (PKU) related aromatic acids had been separated within 15 min, the detection limit was approximately 1.5 x 10(-9) mol for 4-hydroxyphenylacetic acid.
KeywordCapillary Electrophoresis Aromatic Acids Phenylketonuria
Indexed BySCI
Language英语
WOS IDWOS:000171295000003
PublisherFENXI HUAXUE
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76970
Collection中国科学院化学研究所
Corresponding AuthorChang, LW
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Guo, Q,Chang, LW,Chen, Y. Capillary electrophoresis of aromatic acids in urine - Applied to the diagnosis of phenylketonuria[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2001,29(9):1000-1002.
APA Guo, Q,Chang, LW,&Chen, Y.(2001).Capillary electrophoresis of aromatic acids in urine - Applied to the diagnosis of phenylketonuria.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,29(9),1000-1002.
MLA Guo, Q,et al."Capillary electrophoresis of aromatic acids in urine - Applied to the diagnosis of phenylketonuria".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 29.9(2001):1000-1002.
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