ICCAS OpenIR
Capillary electrophoresis of neurotransmitters under the control of radial electric field
Zhu, Y; Chen, Y
2001-06-01
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume29Issue:6Pages:661-663
AbstractSeparations of neurotransmitters such as dopamine (DA), serotonin (5-HA), norepinephrine (NE) and epinephrine (E) were performed successfully using a homemade electric field modulated capillary electrophoretic system, which could offer both radial and axial electric fields with only one high voltage power supply. DA and 5-HT were eluted simulaneously and could not be resolved in 0.01 mol/L phosphate buffer at pH 2.5. Alcohol additives, such as methanol, ethanol or l-propanol were added to the buffer to change the solvation shell of the solutes, which changed their effective sizes and electrophoretic mobilities of the solutes accordingly. The optimum composition was a buffer of 20% ( V/V) 1-propanol, with resulted resolutions 0.74 (DA/5-HT), 0.56(5-HT/NE) and 0.77 (NE/E). If a positive radial voltage of 6.6 kV was applied, the resolutions were improved to 1.48, 0.71 and 1.32, respectively.
KeywordCapillary Electrophoresis Neurotransmitter Separation Radial Electric Field Control
Indexed BySCI
Language英语
WOS IDWOS:000169539000011
PublisherFENXI HUAXUE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76856
Collection中国科学院化学研究所
Corresponding AuthorZhu, Y
Affiliation1.Chinese Acad Prevent Med, Inst Environm Hlth Monitoring, Beijing 100021, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Y,Chen, Y. Capillary electrophoresis of neurotransmitters under the control of radial electric field[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2001,29(6):661-663.
APA Zhu, Y,&Chen, Y.(2001).Capillary electrophoresis of neurotransmitters under the control of radial electric field.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,29(6),661-663.
MLA Zhu, Y,et al."Capillary electrophoresis of neurotransmitters under the control of radial electric field".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 29.6(2001):661-663.
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