ICCAS OpenIR
An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy
Chen, YW; Li, L; Zhang, MH; Shen, T
2001-05-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume46Issue:10Pages:823-827
AbstractMeso-tetrahydroxylphenyl chlorin (m-THPC) is one of the most efficient prospective sensitizers used in photodynamic therapy (PDT). ESR spectroscopy, fluorescence quenching experiments and cyclic voltammogram measurement were used to study its redox properties. The results showed that the ability of m-THPC generating superoxide radical anions was very strong, and the rate constant of In-THPC fluorescence quenching by oxygen k(q) (O-2) = 1.46 x 10(10) mol(-1).s(-1). The values of fluorescence quenching rate constant of m-THPC by some other electron accepters, such as methyl viologen (MV2+) and anthraquinone (An), were also measured. And they were k(q) (MV2+) = 5.51 x 10(9) mol(-1).s(-1), k(q) (An) = 7.81 x 10(9) mol(-1).s(-1). The oxidation potential of m-THPC was examined to be +0.62 V (vs. NHE) in acetonitrile. All these suggested that m-THPC should be a much stronger electron donor than photofrin, the currently used in clinical photodrug, and may react easily through electron transfer with biological matter to yield various radicals. So it seemed reasonable that the type I reaction may play an important role in the high activity of m-THPC-PDT.
KeywordMeso-tetrahydroxylphenyl Chlorin Photodynamic Therapy Redox Properties Superoxide Anion Radical Fluorescence Quenching
Indexed BySCI
Language英语
WOS IDWOS:000169045500007
PublisherSCIENCE PRESS
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76816
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Chen, YW,Li, L,Zhang, MH,et al. An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy[J]. CHINESE SCIENCE BULLETIN,2001,46(10):823-827.
APA Chen, YW,Li, L,Zhang, MH,&Shen, T.(2001).An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy.CHINESE SCIENCE BULLETIN,46(10),823-827.
MLA Chen, YW,et al."An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy".CHINESE SCIENCE BULLETIN 46.10(2001):823-827.
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