ICCAS OpenIR
Microbial desymmetrization of 3-arylglutaronitriles, an unusual enhancement of enantioselectivity in the presence of additives
Wang, MX; Liu, CS; Li, JS; Meth-Cohn, O
2000-10-28
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume41Issue:44Pages:8549-8552
AbstractIn the presence of an organic additive such as acetone or beta -cyclodextrin or in a biphasic system of hexane and aqueous phosphate buffer, microbial desymmetrization of 3-arylglutaronitriles catalyzed by Rhodococcus sp. AJ270 cells proceeded regiospecifically and enantioselectively to produce S-(+)-3-aryl-4-cyanobutyric acids in high enantiomeric excess. Convenient chemoenzymatic syntheses of optically active R-(-)-4-amino-3-phenylbutyric acid and 4R-(-)-4-phenyltetrahydropyran-2-one are described. (C) 2000 Elsevier Science Ltd. All rights reserved.
Indexed ByIC ; CCR ; SCI
Language英语
WOS IDWOS:000165150200030
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76500
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Univ Sunderland, Dept Chem, Sunderland SR1 3SD, Durham, England
Recommended Citation
GB/T 7714
Wang, MX,Liu, CS,Li, JS,et al. Microbial desymmetrization of 3-arylglutaronitriles, an unusual enhancement of enantioselectivity in the presence of additives[J]. TETRAHEDRON LETTERS,2000,41(44):8549-8552.
APA Wang, MX,Liu, CS,Li, JS,&Meth-Cohn, O.(2000).Microbial desymmetrization of 3-arylglutaronitriles, an unusual enhancement of enantioselectivity in the presence of additives.TETRAHEDRON LETTERS,41(44),8549-8552.
MLA Wang, MX,et al."Microbial desymmetrization of 3-arylglutaronitriles, an unusual enhancement of enantioselectivity in the presence of additives".TETRAHEDRON LETTERS 41.44(2000):8549-8552.
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