ICCAS OpenIR
The aggregation and phase separation behavior of a hydrophobically modified poly(N-isopropylacrylamide)
Shi, XY; Li, JB; Sun, CM; Wu, SK
2000-12-15
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume175Issue:1-2Pages:41-49
AbstractTo study the water solution properties of a hydrophobically modified poly(N-isopropylacrylamide) (PNIPAM) that is temperature-sensitive, the copolymer of N-isopropylacrylamide (NIPAM) and octadecylacrylate (ODA) was synthesized. The aggregation behavior of the copolymer was studied by surface tension and fluorescent probe methods. Simultaneously, the phenomenon of LCST (Lower Critical Solution Temperature) of the copolymer in aqueous solution with the increase of temperature was also studied by using the fluorescent probe method. Results showed that phase separation occurred in aqueous solution of the copolymer when the temperature was increased to its LCST. The pi-A isotherms for the copolymer molecules, as an insoluble monolayer on the water-air interface, was determined by the Langmuir-Blodgett method. The abnormal phenomenon, which the monolayer of the copolymer molecules became more condensed and more condensed with the increase of temperature, was observed. It further indicated that phase separation of the copolymer occurred from another angle. In addition, to prove the thermo-sensitive effect of the copolymer on the release behavior of liposomes, small unilamellar vesicles entrapped with 5(6)-carboxyfluorescein (5(6)-CF) were coated with the copolymer. We found that the coating of the copolymer resulted in reduction of the release below 30 degrees C and enhancement of the release above 30 degrees C. It indicates that there are obvious interactions between the copolymer and liposomes. (C) 2000 Elsevier Science B.V. All rights reserved.
KeywordWater-soluble Polymer Poly(N-isopropylacrylamide) Aggregation Phase Separation Fluorescent Probe
Indexed ByISTP ; SCI
Language英语
WOS IDWOS:000089562300006
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76492
Collection中国科学院化学研究所
Corresponding AuthorWu, SK
Affiliation1.Chinese Acad Sci, Inst Photog Chem, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Max Planck Inst Colloid & Interface Sci, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Photog Chem, Int Joint Lab, Beijing 100101, Peoples R China
4.Beijing Inst Technol, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Shi, XY,Li, JB,Sun, CM,et al. The aggregation and phase separation behavior of a hydrophobically modified poly(N-isopropylacrylamide)[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2000,175(1-2):41-49.
APA Shi, XY,Li, JB,Sun, CM,&Wu, SK.(2000).The aggregation and phase separation behavior of a hydrophobically modified poly(N-isopropylacrylamide).COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,175(1-2),41-49.
MLA Shi, XY,et al."The aggregation and phase separation behavior of a hydrophobically modified poly(N-isopropylacrylamide)".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 175.1-2(2000):41-49.
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