ICCAS OpenIR
A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution
Wu, C; Jim, TF; Gan, Z; Zhao, Y; Wang, S
2000-05-01
Source PublicationPOLYMER
ISSN0032-3861
Volume41Issue:10Pages:3593-3597
AbstractWater insoluble poly(epsilon-caprolactone) (PCL) was micronized into narrowly distributed stable nanoparticles. The biodegradation of such PCL nanoparticles in the presence of the enzyme, Lipase PS, was monitored by using laser light scattering because the scattering intensity is directly related to the particle concentration. The PCL and enzyme concentration dependence of the biodegradation rate supports a heterogeneous catalytic kinetics in which we have introduced an additional equilibrium between the inactive and active enzyme/substrate complexes. The initial rate equation derived on the basis of this mechanism was used to successfully explain the influence of surfactant, pH and temperature on the enzymatic biodegradation. Our results confirmed that both the adsorption and the enzymatic catalysis were important for the biodegradation of the PCL nanoparticles. (C) 2000 Elsevier Science Ltd. All rights reserved.
KeywordPoly(Epsilon-caprolactone) Nanoparticles Enzyme/substrate Complexes Lipase Ps
Indexed BySCI
Language英语
WOS IDWOS:000085388300010
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76460
Collection中国科学院化学研究所
Corresponding AuthorWu, C
Affiliation1.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
2.Univ Sci & Technol China, Open Lab Bondselect Chem, Dept Phys Chem, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Changchun Inst Appl Chem, Polymer Phys Lab, Changchun 130022, Peoples R China
4.Chinese Acad Sci, Inst Chem, Lab Membranes & Med Polymers, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wu, C,Jim, TF,Gan, Z,et al. A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution[J]. POLYMER,2000,41(10):3593-3597.
APA Wu, C,Jim, TF,Gan, Z,Zhao, Y,&Wang, S.(2000).A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution.POLYMER,41(10),3593-3597.
MLA Wu, C,et al."A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution".POLYMER 41.10(2000):3593-3597.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu, C]'s Articles
[Jim, TF]'s Articles
[Gan, Z]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu, C]'s Articles
[Jim, TF]'s Articles
[Gan, Z]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, C]'s Articles
[Jim, TF]'s Articles
[Gan, Z]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.