ICCAS OpenIR
Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and epsilon-caprolactone
Cai, Q; Bei, JZ; Wang, SG
2000
Source PublicationJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
ISSN0920-5063
Volume11Issue:3Pages:273-288
AbstractA series of tri-component copolymers was synthesized by ring opening copolymerization of cyclic lactones, i.e. glycolide, L-lactide, and caprolactone, using stannous octoate as a catalyst. Various techniques, including FT-IR, H-1 NMR, DSC, X-ray diffraction, tensile strength, and contact angle measurements, were used to elucidate structural characteristics, thermal behavior mechanical properties, and hydrophilicity of the resulting copolymers. Data showed that the properties of these copolymers could be modulated by adjusting the composition of the copolymers. The DSC and X-ray analysis demonstrated amorphous structures for most of the PGLC copolyesters. The degradation behavior of these PGLC copolymers had been studied in vitro, i.e. in 0.10 M pH 7.4 phosphate buffer solution (PBS). The degradation was monitored by intrinsic viscosity and weight loss measurements. SEM and GPC were also used to monitor the morphology and molecular weight change during degradation. The PGLC copolymers were shown to have variable degradation rates, and most of them could disappear within a few months due to their amorphous structure and low glass transition temperature.
KeywordPolyglycolide Polylactide Polycaprolactone Degradability Hydrophilicity Tri-component Copolyester
Indexed BySCI
Language英语
WOS IDWOS:000087001500003
PublisherVSP BV
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76236
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Cai, Q,Bei, JZ,Wang, SG. Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and epsilon-caprolactone[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2000,11(3):273-288.
APA Cai, Q,Bei, JZ,&Wang, SG.(2000).Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and epsilon-caprolactone.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,11(3),273-288.
MLA Cai, Q,et al."Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and epsilon-caprolactone".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 11.3(2000):273-288.
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