ICCAS OpenIR
Enantioselective biotransformations of racemic alpha-substituted phenylacetonitriles and phenylacetamides using Rhodococcus sp AJ270
Wang, MX; Lu, G; Ji, GJ; Huang, ZT; Meth-Cohn, O; Colby, J
2000-03-24
Source PublicationTETRAHEDRON-ASYMMETRY
ISSN0957-4166
Volume11Issue:5Pages:1123-1135
AbstractRhodococcus sp. AJ270 is an efficient whole-cell system able to catalyze the stereoselective conversions of racemic alpha-substituted phenylacetonitriles and amides under very mild conditions into enantiopure carboxylic acids and derivatives. The nitrile hydratase involved generally has a broad substrate spectrum against phenylacetonitriles irrespective of the electronic nature of the alpha-substituent while the amidase is very sensitive to both the electronic and steric factors of the substituent of amides. The overall enantioselectivity of nitrile hydrolysis is mainly determined by the combination of selectivities of nitrile hydratase and of amidase, with the latter being a major contributor. The amidase has high S-enantiocontrol against amides while the nitrile hydratase exhibits low R-selectivity against nitriles. The scope and limitations of this enantioselective biotransformation process are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
Indexed ByIC ; CCR ; SCI
Language英语
WOS IDWOS:000086642300012
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:76[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76216
Collection中国科学院化学研究所
Corresponding AuthorWang, MX
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Univ Sunderland, Sch Hlth Sci, Sunderland ST1 3SD, England
Recommended Citation
GB/T 7714
Wang, MX,Lu, G,Ji, GJ,et al. Enantioselective biotransformations of racemic alpha-substituted phenylacetonitriles and phenylacetamides using Rhodococcus sp AJ270[J]. TETRAHEDRON-ASYMMETRY,2000,11(5):1123-1135.
APA Wang, MX,Lu, G,Ji, GJ,Huang, ZT,Meth-Cohn, O,&Colby, J.(2000).Enantioselective biotransformations of racemic alpha-substituted phenylacetonitriles and phenylacetamides using Rhodococcus sp AJ270.TETRAHEDRON-ASYMMETRY,11(5),1123-1135.
MLA Wang, MX,et al."Enantioselective biotransformations of racemic alpha-substituted phenylacetonitriles and phenylacetamides using Rhodococcus sp AJ270".TETRAHEDRON-ASYMMETRY 11.5(2000):1123-1135.
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