ICCAS OpenIR
Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species
Wu, T; Shen, JQ; Song, AM; Chen, S; Zhang, MH; Shen, T
2000-08-01
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume57Issue:1Pages:14-21
AbstractA novel method has been employed to prepare 2-butylamino-2-demethoxy hypocrellin A (BADMHA) and 3-butylamino-2-demethoxy hypocrellin B (BADMHB). Both compounds exhibit stronger absorption at the phototherapeutic window (600-900: nm). The spin trapping and spin counteraction studies have shown that they are both efficient generators of the active oxygen (O-1(2), O-2(.-)) in the aerobic condition. Under the anaerobic condition they generate non-oxygen free radical (semiquinone radical anion), and the active oxygen mechanism of photosensitization can be converted into cion-oxygen free radical mechanism with the depletion of oxygen. The quantum yields of O-1(2) generation of BADMHA and BADMHB are 0.46 and 0.44, respectively. Both are lower than those of their parent compounds HA and HE. But the productions of superoxide anion are enhanced significantly compared with HA and HE, indicating they are both favorable Type I phototherapeutic agents. (C) 2000 Elsevier Science S.A. All rights reserved.
KeywordHypocrellins Photodynamic Action Phototherapeutic Window Active Oxygen Epr Photopotentiation
Indexed BySCI
Language英语
WOS IDWOS:000090033900002
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76150
Collection中国科学院化学研究所
Corresponding AuthorZhang, MH
AffiliationChinese Acad Sci, Ctr Mol Sci, Inst Photog Chem, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wu, T,Shen, JQ,Song, AM,et al. Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2000,57(1):14-21.
APA Wu, T,Shen, JQ,Song, AM,Chen, S,Zhang, MH,&Shen, T.(2000).Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,57(1),14-21.
MLA Wu, T,et al."Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 57.1(2000):14-21.
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