ICCAS OpenIR
A selective fluorimetric method for the determination of some beta-lactamic antibiotics
Ma, QL; Yang, JH; Wu, X; Huang, F; Sun, LM
2000
Source PublicationANALYTICAL LETTERS
ISSN0003-2719
Volume33Issue:13Pages:2689-2699
AbstractBased on the reaction between acetylacetone-folmaldehyde and beta-lactamic antibiotics at pH=4.0, in which product can emit strong fluorescence, a selective simple fluorimetric method is described for the determination of both alpha-aminocephalosporins (namely cepharadine and cefalexin) and 6-aminopenicillanic acid (6-APA) in pure form and in pharmaceutical form. Other beta-lactamic antibiotics free from alpha-amino group do not interfere with the assay. The linear ranges are 1.0x10(-4)-8.0x10(-2) mg/ml,2.0x10(-4)-3.0x10(-2) mg/ml and 3.0x10(-4)-2.0x10(-2) mg/ml for cepharadine, cefalexin and 6-APA, respectively. Their detection limits (S/N=3) are 3.0x10(-5)mg/ml, 4.0x10(-5)mg/ml and 6.0x10(-5) mg/ml.
KeywordFluorimetry Beta-lactamic Antibiotics Cephalosporins Penicillins
Indexed BySCI
Language英语
WOS IDWOS:000089580300007
PublisherMARCEL DEKKER INC
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/76066
Collection中国科学院化学研究所
Corresponding AuthorYang, JH
Affiliation1.Shandong Univ, Key Lab Colloid & Interface Chem Educ Minist, Sch Chem & Environm Sci, Jinan 250100, Peoples R China
2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Ma, QL,Yang, JH,Wu, X,et al. A selective fluorimetric method for the determination of some beta-lactamic antibiotics[J]. ANALYTICAL LETTERS,2000,33(13):2689-2699.
APA Ma, QL,Yang, JH,Wu, X,Huang, F,&Sun, LM.(2000).A selective fluorimetric method for the determination of some beta-lactamic antibiotics.ANALYTICAL LETTERS,33(13),2689-2699.
MLA Ma, QL,et al."A selective fluorimetric method for the determination of some beta-lactamic antibiotics".ANALYTICAL LETTERS 33.13(2000):2689-2699.
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