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Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro
Zhang, XY; Cao, EH; Sun, XG; Bai, CL
2000-11-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume45Issue:21Pages:1959-1963
AbstractTelomere plays an important role in cellular processes, such as cell aging, death and carcinogenisis. Having special sequences, it can form quadruplex structure in vitro. Circular dichroism (CD) spectroscopic studies show that TTAGGG, (TTAGGG)(2) and (TTAGGG)(4) can all form quadruplex in vitro and exist mainly as parallel quadruplex without metal ions. Both K+ and Na+ can stabilize the tetrameric structure and facilitate the forming of anti-parallel conformation. Furthermore, the conformations of quadruplex can also be affected by sequence length, the nature and concentration of metal ions.
KeywordHuman Telomere Quadruplex Conformation Cd Spectrum K++++ Na++++ Cation Concentration
Indexed BySCI
Language英语
WOS IDWOS:000165415400009
PublisherSCIENCE PRESS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/75980
Collection中国科学院化学研究所
Corresponding AuthorCao, EH
Affiliation1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhang, XY,Cao, EH,Sun, XG,et al. Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro[J]. CHINESE SCIENCE BULLETIN,2000,45(21):1959-1963.
APA Zhang, XY,Cao, EH,Sun, XG,&Bai, CL.(2000).Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro.CHINESE SCIENCE BULLETIN,45(21),1959-1963.
MLA Zhang, XY,et al."Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro".CHINESE SCIENCE BULLETIN 45.21(2000):1959-1963.
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