"Protein-only" or "virino" in prion diseases?
Yang, CM; Chen, Y
Abstract60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted. In order to resolve the prion enigma in neuroscience, it is suggested that both technical and concept barriers remain to be crossed. Since prion research is a multi-interdisciplinary subject, this view is intended to both facilitate a better understanding of prion phenomenon by more scientists in natural science, and invite scientists outside the fields of molecular genetics and protein science for collaboration.
KeywordPrions Mad Cow Disease Neurodegenerative Disorder Subviral Pathogen Prion Radical
Indexed BySCI
WOS IDWOS:000085980500022
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYang, CM
Affiliation1.Univ Calif San Diego, Inst Life Sci & Hlth, La Jolla, CA 92093 USA
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
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GB/T 7714
Yang, CM,Chen, Y. "Protein-only" or "virino" in prion diseases?[J]. CHINESE SCIENCE BULLETIN,2000,45(3):285-288.
APA Yang, CM,&Chen, Y.(2000)."Protein-only" or "virino" in prion diseases?.CHINESE SCIENCE BULLETIN,45(3),285-288.
MLA Yang, CM,et al.""Protein-only" or "virino" in prion diseases?".CHINESE SCIENCE BULLETIN 45.3(2000):285-288.
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