ICCAS OpenIR
Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor
Xiu, GH; Jiang, L; Li, P
2000-11-01
Source PublicationINDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
ISSN0888-5885
Volume39Issue:11Pages:4054-4062
AbstractThe immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor was studied theoretically. An exact solution was developed for a first-order reaction coupled with the intraparticle and external mass transfers. The time courses of substrate concentration and conversion as well as the purity and yield of the desired product were predicted by the exact solution, and the effects of the intraparticle and external mass-transfer resistances on the enzyme enantioselectivity were also quantitatively discussed. A simple approximate solution, taking into account the simultaneous reaction/external and intraparticle mass-transfer processes for the immobilized enzyme, was presented to predict the purity and yield of the desired product. For a competitive Michaelis-Menten kinetic resolution process, the effects of the competitive inhibitions of substrate and free water on the resolution process were analyzed by the orthogonal collocation method. The effectiveness factor and the effective enantiomeric ratio were predicted by the domain division method for the simplest case that the resolution process is at pseudo steady state and the inhibition effect, of free water can be neglected.
Indexed BySCI
Language英语
WOS IDWOS:000165191400010
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/75734
Collection中国科学院化学研究所
Corresponding AuthorXiu, GH
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Shenyang Inst Chem Technol, Dept Chem Engn, Shenyang 110021, Peoples R China
Recommended Citation
GB/T 7714
Xiu, GH,Jiang, L,Li, P. Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2000,39(11):4054-4062.
APA Xiu, GH,Jiang, L,&Li, P.(2000).Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,39(11),4054-4062.
MLA Xiu, GH,et al."Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a batch reactor".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 39.11(2000):4054-4062.
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