ICCAS OpenIR
Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation
Yang, LJ; Liu, MZ; Deng, WL; Wang, C; Bai, CL; Kan, LS
1999-01-11
Source PublicationBIOPHYSICAL CHEMISTRY
ISSN0301-4622
Volume76Issue:1Pages:25-34
AbstractThree triple-helical hairpin DNAs with substitution of 5-bromocytosine for cytosine in different strands have been investigated by molecular mechanics and Raman spectroscopy. The stability of the three substituted triplexes were compared with the corresponding unsubstituted tripler DNA by the molecular mechanics method. Base stacking interactions and strand-strand interactions of each tripler were analyzed in detail. Sugar conformations in these triplexes have been determined by both vibrational spectroscopy and molecular dynamics simulation. The hairpin triplexes with substitution occurring in strand I or both in strands I and III have the main sugar conformation of CS'-endo, while the tripler with substitution occurring in strand III is the combination of C3'-endo and C2'-endo sugar conformation. Theoretical results are basically in agreement with experiments. (C) 1999 Elsevier Science B.V. All rights reserved.
KeywordStability Conformation Hairpin Triplex 5-bromodeoxycytosine
Indexed BySCI
Language英语
WOS IDWOS:000078369400003
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/75274
Collection中国科学院化学研究所
Corresponding AuthorBai, CL
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Acad Sinica, Inst Chem, Taipei, Taiwan
Recommended Citation
GB/T 7714
Yang, LJ,Liu, MZ,Deng, WL,et al. Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation[J]. BIOPHYSICAL CHEMISTRY,1999,76(1):25-34.
APA Yang, LJ,Liu, MZ,Deng, WL,Wang, C,Bai, CL,&Kan, LS.(1999).Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation.BIOPHYSICAL CHEMISTRY,76(1),25-34.
MLA Yang, LJ,et al."Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation".BIOPHYSICAL CHEMISTRY 76.1(1999):25-34.
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