ICCAS OpenIR
Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens
Deng, XM; Li, XH; Yuan, ML; Li, XW; Xiong, CD; Huang, ZT; Jia, WX
1999
Source PublicationCHINESE JOURNAL OF POLYMER SCIENCE
ISSN0256-7679
Volume17Issue:3Pages:265-270
AbstractPoly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods. The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0 mu m, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues, such as the liver, spleen and intestinal peyer's patches, following oral administration. The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.
KeywordPoly-dl-lactide-poly(Ethylene Glycol) Vibrio Cholera Antigen Lanthanum Acetate Microsphere Protective Ratio
Indexed BySCI
Language英语
WOS IDWOS:000080631100009
PublisherSPRINGER-VERLAG SINGAPORE PTE LTD
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/75054
Collection中国科学院化学研究所
Corresponding AuthorDeng, XM
Affiliation1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
3.W China Univ Med Sci, Chengdu 610041, Peoples R China
Recommended Citation
GB/T 7714
Deng, XM,Li, XH,Yuan, ML,et al. Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens[J]. CHINESE JOURNAL OF POLYMER SCIENCE,1999,17(3):265-270.
APA Deng, XM.,Li, XH.,Yuan, ML.,Li, XW.,Xiong, CD.,...&Jia, WX.(1999).Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens.CHINESE JOURNAL OF POLYMER SCIENCE,17(3),265-270.
MLA Deng, XM,et al."Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens".CHINESE JOURNAL OF POLYMER SCIENCE 17.3(1999):265-270.
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