ICCAS OpenIR
A method for the preparation of polymeric nanocapsules without stabilizer
Lu, Z; Bei, JZ; Wang, SG
1999-08-27
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume61Issue:1-2Pages:107-112
AbstractIn this communication poly(L-lactide) (PLLA) nanocapsules containing bovine serum albumin (BSA) were prepared by means of a modified W/O/W double emulsion technology. A mixture of glycerin and water was used instead of the traditional stabilizer system in the preparation of polymeric nanocapsules. The preliminary results showed that the high viscosity of the mixture and the hydroxyl group of the glycerin were helpful to the formation of the nanocapsules. The prepared nanocapsules had a similar spherical form. By comparison of different polymers of poly(L-lactide) and polycaprolactone-poly(ethylene oxide) block copolymer (PCE), it was found that the entrapment efficiency of the BSA was strongly dependent on the hydrophilicity of the polymer. A lower entrapment efficiency of BSA and nanocapsules with smaller size were obtained when the relative hydrophilic PCE polymer was used as the entrapping material. (C) 1999 Elsevier Science B.V. All rights reserved.
KeywordPolymeric Nanocapsules W/o/w Emulsion Bovine Serum Albumin Poly(L-lactide) Polycaprolactone-poly(Ethylene Oxide) Block Copolymer (Pce)
Indexed BySCI
Language英语
WOS IDWOS:000082780600010
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/75010
Collection中国科学院化学研究所
Corresponding AuthorWang, SG
AffiliationChinese Acad Sci, Inst Chem, PCLCC, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Lu, Z,Bei, JZ,Wang, SG. A method for the preparation of polymeric nanocapsules without stabilizer[J]. JOURNAL OF CONTROLLED RELEASE,1999,61(1-2):107-112.
APA Lu, Z,Bei, JZ,&Wang, SG.(1999).A method for the preparation of polymeric nanocapsules without stabilizer.JOURNAL OF CONTROLLED RELEASE,61(1-2),107-112.
MLA Lu, Z,et al."A method for the preparation of polymeric nanocapsules without stabilizer".JOURNAL OF CONTROLLED RELEASE 61.1-2(1999):107-112.
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