Knowledge Management System Of Institute of Chemistry，CAS
| A method for the preparation of polymeric nanocapsules without stabilizer | |
| Lu, Z; Bei, JZ; Wang, SG | |
| 1999-08-27 | |
| Source Publication | JOURNAL OF CONTROLLED RELEASE
 |
| ISSN | 0168-3659 |
| Volume | 61Issue:1-2Pages:107-112 |
| Abstract | In this communication poly(L-lactide) (PLLA) nanocapsules containing bovine serum albumin (BSA) were prepared by means of a modified W/O/W double emulsion technology. A mixture of glycerin and water was used instead of the traditional stabilizer system in the preparation of polymeric nanocapsules. The preliminary results showed that the high viscosity of the mixture and the hydroxyl group of the glycerin were helpful to the formation of the nanocapsules. The prepared nanocapsules had a similar spherical form. By comparison of different polymers of poly(L-lactide) and polycaprolactone-poly(ethylene oxide) block copolymer (PCE), it was found that the entrapment efficiency of the BSA was strongly dependent on the hydrophilicity of the polymer. A lower entrapment efficiency of BSA and nanocapsules with smaller size were obtained when the relative hydrophilic PCE polymer was used as the entrapping material. (C) 1999 Elsevier Science B.V. All rights reserved. |
| Keyword | Polymeric Nanocapsules W/o/w Emulsion Bovine Serum Albumin Poly(L-lactide) Polycaprolactone-poly(Ethylene Oxide) Block Copolymer (Pce) |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000082780600010 |
| Publisher | ELSEVIER SCIENCE BV |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/75010 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Wang, SG |
| Affiliation | Chinese Acad Sci, Inst Chem, PCLCC, Beijing 100080, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Z,Bei, JZ,Wang, SG. A method for the preparation of polymeric nanocapsules without stabilizer[J]. JOURNAL OF CONTROLLED RELEASE,1999,61(1-2):107-112. |
| APA | Lu, Z,Bei, JZ,&Wang, SG.(1999).A method for the preparation of polymeric nanocapsules without stabilizer.JOURNAL OF CONTROLLED RELEASE,61(1-2),107-112. |
| MLA | Lu, Z,et al."A method for the preparation of polymeric nanocapsules without stabilizer".JOURNAL OF CONTROLLED RELEASE 61.1-2(1999):107-112. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment