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ESR evidence of the photogeneration of free radicals (GDHB(center dot-), O-2(center dot-))and singlet oxygen (O-1(2)) by 15-deacetyl-13-glycine-substituted hypocrellin B
Song, YZ; An, JY; Jiang, LJ
1999-10-18
Source PublicationBIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
ISSN0304-4165
Volume1472Issue:1-2Pages:307-313
Abstract15-Deacetyl-13-glycine-substituted hypocrellin B (GDHB) is a new type of hypocrellin derivative with an enhanced red absorption longer than 600 nm and water solubility. Visible light ( > 470 mm) irradiation of an anaerobic aqueous solution of GDHB, the formation of GDHB(.-) was detected by an ESR method in the absence or presence of electron donor. When exposed to oxygen, superoxide anion radical and singlet oxygen were formed. The superoxide anion radical was generated by GDHB(.-) via electron transfer to oxygen and this process was significantly enhanced by the presence of electron donors. Singlet oxygen (O-1(2)) was also formed in the photosensitization of GDHB in aerobic solution and 1,4-diazabicyclo [2,2,2] octane (DABCO), sodium azide (NaN3) and histidine inhibited the generation of O-1(2). A 9,10-diphenyl antracene (DPA)bleaching method was used to determine the quantum yield of O-1(2) generated from GDHB photosensitization. The O-1(2) quantum yield was estimated to be 0.65. With the depletion of oxygen, the accumulation of GDHB(.-) would replace that of O-1(2) Evidence accumulated that the photodynamic action of GDHB may proceed via both type I and type II mechanisms and that a type II mechanism will be transformed into a type I mechanism as oxygen gets depleted. (C) 1999 Elsevier Science B.V. All rights reserved.
Keyword15-deacetyl-13-glycine-substituted Hypocrellin b Semiquinone Anion Radical Superoxide Radical Anion Singlet Oxygen Esr Spin Trapping
Indexed BySCI
Language英语
WOS IDWOS:000083347800033
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/74836
Collection中国科学院化学研究所
Corresponding AuthorJiang, LJ
AffiliationChinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Song, YZ,An, JY,Jiang, LJ. ESR evidence of the photogeneration of free radicals (GDHB(center dot-), O-2(center dot-))and singlet oxygen (O-1(2)) by 15-deacetyl-13-glycine-substituted hypocrellin B[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1999,1472(1-2):307-313.
APA Song, YZ,An, JY,&Jiang, LJ.(1999).ESR evidence of the photogeneration of free radicals (GDHB(center dot-), O-2(center dot-))and singlet oxygen (O-1(2)) by 15-deacetyl-13-glycine-substituted hypocrellin B.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1472(1-2),307-313.
MLA Song, YZ,et al."ESR evidence of the photogeneration of free radicals (GDHB(center dot-), O-2(center dot-))and singlet oxygen (O-1(2)) by 15-deacetyl-13-glycine-substituted hypocrellin B".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1472.1-2(1999):307-313.
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