ICCAS OpenIR
Effect of selective substitution of 5-bromocytosine on conformation of DNA triple helices
Liu, MZ; Yang, LJ; Deng, WL; Su, M; Wang, C; Lin, SB; Kan, LS; Bai, CL
1998-04-01
Source PublicationJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN0739-1102
Volume15Issue:5Pages:895-903
AbstractThree tripler DNAs containing 5-bromocytosine[C-Br] were studied by vibrational spectroscopy and molecular modelling. Firstly, three oligodeoxypyrimidines of 5'-(TC)3-T4-((CT)-C-Br)3 [(CC)-C-Br], 5'-((TC)-C-Br)3-T4-(CT)3 [(CC)-C-Br] and 5'-((TC)-C-Br)3-T4-((CT)-C-Br)3 [(CC)-C-Br-C-Br] were synthesized and then reacted with an oligodeoxypurine of 5'-(AG)(3) at pH=4.5 in phosphate buffer respectively to form three comparative hairpin tripler named CY,YC and YY. The results of FT-Raman and IR revealed that YY is almost in A-like form, CY and YC are combinations of A-like form and B-like form, but A-form dominates in CY while B-form is equivalent as A-form in YC. The result is consistent with the theoretical analysis.
Indexed BySCI
Language英语
WOS IDWOS:000073642200007
PublisherADENINE PRESS INC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/74548
Collection中国科学院化学研究所
Corresponding AuthorKan, LS
Affiliation1.Acad Sinica, Inst Chem, Taipei, Taiwan
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, MZ,Yang, LJ,Deng, WL,et al. Effect of selective substitution of 5-bromocytosine on conformation of DNA triple helices[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,1998,15(5):895-903.
APA Liu, MZ.,Yang, LJ.,Deng, WL.,Su, M.,Wang, C.,...&Bai, CL.(1998).Effect of selective substitution of 5-bromocytosine on conformation of DNA triple helices.JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,15(5),895-903.
MLA Liu, MZ,et al."Effect of selective substitution of 5-bromocytosine on conformation of DNA triple helices".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 15.5(1998):895-903.
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