ICCAS OpenIR
Atomic force microscopy observation of the condensates of the spermidine-DNA complexes
Lin, Z; Wang, C; Su, M; Tian, F; Ma, J; Bai, CL
1998-08-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume41Issue:4Pages:418-423
AbstractIn vitro investigation on the condensation of DNA induced by naturally occurring polyamines can provide useful insights into the packaging state of DNA in vivo, which is closely related to the mechanism of the self-regulation or self-switching of the gene expression. The present paper reports the high resolution AFM observations of the condensates of spermidine-DNA complexes. It was found that the spermidine can directly condense the DNA into toroidal structures. The formation of this special structure is greatly influenced by the dynamic factors such as the concentrations and the reaction time. Close examination revealed that the toroids were constructed by many particles stacked and squeezed together. Our observations indicate that the dynamic process of the toroid formation may be a spiral wound process of the globular subunits.
KeywordToroidal Condensates Spermidine Afm Spiral Wound Process Of Globular Subunits
Indexed BySCI
Language英语
WOS IDWOS:000075346800011
PublisherSCIENCE PRESS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/74178
Collection中国科学院化学研究所
Corresponding AuthorBai, CL
AffiliationAcad Sinica, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Lin, Z,Wang, C,Su, M,et al. Atomic force microscopy observation of the condensates of the spermidine-DNA complexes[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1998,41(4):418-423.
APA Lin, Z,Wang, C,Su, M,Tian, F,Ma, J,&Bai, CL.(1998).Atomic force microscopy observation of the condensates of the spermidine-DNA complexes.SCIENCE IN CHINA SERIES B-CHEMISTRY,41(4),418-423.
MLA Lin, Z,et al."Atomic force microscopy observation of the condensates of the spermidine-DNA complexes".SCIENCE IN CHINA SERIES B-CHEMISTRY 41.4(1998):418-423.
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