ICCAS OpenIR
Protein Sensing and Cell Discrimination Using a Sensor Array Based on Nanomaterial-Assisted Chemiluminescence
Kong, Hao1; Liu, Da1,2; Zhang, Sichun1; Zhang, Xingrong1
2011-03-15
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume83Issue:6Pages:1867-1870
AbstractCross-reactive sensor arrays, known as "chemical noses", offer an alternative to time-consuming analytical methods. Here, we report a sensor array based on nanomaterial-assisted chemiluminescence (CL) for protein sensing and cell discrimination. We have found that the CL efficiencies are improved to varied degree for a given protein on cell line on catalytic nanomaterials. Distinct CL response patterns as "fingerprints" can be obtained on the array and then identified through linear discriminant analysis (LDA). The sensing of 12 kinds Of proteins at three concentrations, as Well as 12 types. of human cell, lines among normal, cancerous, and metastatic, has been performed. Compared with most fluorescent or colorimetric approaches which rely on the strong interaction between analytes and sensing elements, our array offers the advantage of both sensitivity and reversibility.
DOI10.1021/ac200076c
Indexed BySCI
Language英语
WOS IDWOS:000288182900001
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:84[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73692
Collection中国科学院化学研究所
Corresponding AuthorZhang, Xingrong
Affiliation1.Tsinghua Univ, Dept Chem, Key Lab Atom & Mol Nanosci, Educ Minist, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Kong, Hao,Liu, Da,Zhang, Sichun,et al. Protein Sensing and Cell Discrimination Using a Sensor Array Based on Nanomaterial-Assisted Chemiluminescence[J]. ANALYTICAL CHEMISTRY,2011,83(6):1867-1870.
APA Kong, Hao,Liu, Da,Zhang, Sichun,&Zhang, Xingrong.(2011).Protein Sensing and Cell Discrimination Using a Sensor Array Based on Nanomaterial-Assisted Chemiluminescence.ANALYTICAL CHEMISTRY,83(6),1867-1870.
MLA Kong, Hao,et al."Protein Sensing and Cell Discrimination Using a Sensor Array Based on Nanomaterial-Assisted Chemiluminescence".ANALYTICAL CHEMISTRY 83.6(2011):1867-1870.
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