ICCAS OpenIR
Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum
Zhu, Zhiqiang2,3; Xiong, Caiqiao2,3; Xu, Gaoping4; Liu, Hao5; Zhou, Xiaoyu2,3; Chen, Rui2,3; Peng, Wen-Ping1; Nie, Zongxiu2,3
2011
Source PublicationANALYST
ISSN0003-2654
Volume136Issue:7Pages:1305-1309
AbstractA miniature cylindrical ion trap mass spectrometer (CIT-MS) equipped with an inexpensive mechanical pump was constructed, and used to measure the masses of cells and microparticles generated by laser induced acoustic desorption ionization. Compared with a previous lab scale quadrupole ion trap mass spectrometer (QIT-MS), the novel miniature CIT-MS had smaller volume (the radius r(0) 5 mm), simpler ion trap fabrication and overall instrument construction, required a lower trapping voltage, and reduced the weight, power and cost of the instrument. The CIT-MS was calibrated using standard polystyrene beads of 2.982 mu m diameter. The CIT-MS was used to measure the total dry weight of human red blood cells (RBCs) from a healthy female adult (2.12 x 10(13) Da) and a patient with anemia (1.35 x10(13) Da). The coefficient of variance (CV) for the healthy individual was 21% and that for the patient was 30.4%. The CIT-MS was also applied to guinea pig RBCs and the total dry weight was determined as 1.34 x 0(13) Da with a CV of 37.9%. These measurements are consistent with previous QIT-MS measurements. The new miniaturized instrument has potential for applications in field-portable, biological and aerosol analysis.
DOI10.1039/c0an00911c
Indexed BySCI
Language英语
WOS IDWOS:000288327600005
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73532
Collection中国科学院化学研究所
Corresponding AuthorPeng, Wen-Ping
Affiliation1.Natl Dong Hwa Univ, Dept Phys, Shoufeng 97401, Hualien, Taiwan
2.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
3.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
4.Jiujiang Univ, Sch Sci, Jiujiang 332005, Peoples R China
5.Jiujiang Vocat Univ, Jiujiang 332000, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Zhiqiang,Xiong, Caiqiao,Xu, Gaoping,et al. Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum[J]. ANALYST,2011,136(7):1305-1309.
APA Zhu, Zhiqiang.,Xiong, Caiqiao.,Xu, Gaoping.,Liu, Hao.,Zhou, Xiaoyu.,...&Nie, Zongxiu.(2011).Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum.ANALYST,136(7),1305-1309.
MLA Zhu, Zhiqiang,et al."Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum".ANALYST 136.7(2011):1305-1309.
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