ICCAS OpenIR
Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila
Hou, Qinlong2,3; Jiang, Huoqing1,3; Zhang, Xu2,3; Guo, Chao1,3; Huang, Bo2,3; Wang, Peng2,3; Wang, Tiepeng2,3; Wu, Kaiyuan2; Li, Jian2; Gong, Zhefeng1; Du, Libo4; Liu, Yang4; Liu, Li1; Chen, Chang2
2011
Source PublicationNITRIC OXIDE-BIOLOGY AND CHEMISTRY
ISSN1089-8603
Volume24Issue:1Pages:17-24
AbstractNitric oxide (NO) plays an important role in learning and memory which is essential for animals to adapt to the external environment. However, little is known about the role of NO metabolism in this process. S-nitrosoglutathione reductase (GSNOR) is a key protein in the control of NO metabolism and protein S-nitrosation. To study the relationship between NO metabolism and learning and memory, the expression of gene fdh which is homolog to mammalian GSNOR was modulated by the Gal4/UAS system in Drosophila. The over-expression of the fdh in the central nervous system significantly increased GSNOR activity and induced visual pattern memory defects of Drosophila. The role of fdh in learning and memory was independent of development and was neuron-specific: over-expression of the fdh in the fan-shaped body induced memory defect, while over-expression in the mushroom body did not. The visual pattern memory defect could be rescued by co-expression with exogenous cGMP-dependent protein kinase (PKG). Moreover, fdh over-expression resulted in denitrosation of multiple proteins functionally enriched in vesicle-mediated transport, which is important for learning and memory. These results showed that regulation of NO metabolism plays an important role in learning and memory, and the mechanism may involve both NO-cGMP-PKG signaling pathway and S-nitrosation modification. (C) 2010 Elsevier Inc. All rights reserved.
KeywordNitric Oxide Visual Pattern Memory Formaldehyde Dehydrogenase S-nitrosoglutathione Reductase Drosophila
DOI10.1016/j.niox.2010.09.007
Indexed BySCI
Language英语
WOS IDWOS:000286714100003
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73526
Collection中国科学院化学研究所
Corresponding AuthorLiu, Li
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hou, Qinlong,Jiang, Huoqing,Zhang, Xu,et al. Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila[J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY,2011,24(1):17-24.
APA Hou, Qinlong.,Jiang, Huoqing.,Zhang, Xu.,Guo, Chao.,Huang, Bo.,...&Chen, Chang.(2011).Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila.NITRIC OXIDE-BIOLOGY AND CHEMISTRY,24(1),17-24.
MLA Hou, Qinlong,et al."Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila".NITRIC OXIDE-BIOLOGY AND CHEMISTRY 24.1(2011):17-24.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hou, Qinlong]'s Articles
[Jiang, Huoqing]'s Articles
[Zhang, Xu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hou, Qinlong]'s Articles
[Jiang, Huoqing]'s Articles
[Zhang, Xu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hou, Qinlong]'s Articles
[Jiang, Huoqing]'s Articles
[Zhang, Xu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.