ICCAS OpenIR
Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions
Dong, Zhixin; Mao, Jun; Yang, Muquan; Wang, Dapeng; Bo, Shuqin; Ji, Xiangling
2011-12-20
Source PublicationLANGMUIR
ISSN0743-7463
Volume27Issue:24Pages:15282-15291
AbstractBiocompatible and zwitterionic poly(sulfobetaine methacrylate) (PSBMA) was grafted onto the surface of initiator-modified silica nanopartides via surface-initiated atom transfer radical polymerization. The resultant samples were characterized via nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis. Their molecular weights and molecular weight distributions were determined via gel permeation chromatography after the removal of silica by etching. Moreover, the phase behavior of these polyzwitterionic-grafted silica nanoparticles in aqueous solutions and stability in protein/PBS solutions were systematically investigated. Dynamic light scattering and UV-visible spectroscopy results indicate that the silica-g-PSBMA nanoparticles exhibit an upper critical solution temperature (UCST) in aqueous solutions, which can be controlled by varying the PSBMA molecular weight, ionic strength, silica-g-PSBMA nanoparticle concentration, and solvent polarity. The UCSTs shift toward high temperatures with increasing PSBMA molecular weight and silica-g-PSBMA nanoparticle concentration. However, increasing the ionic strength and solvent polarity leads to a lowering of the UCSTs. The silica-g-PSBMA nanoparticles are stable for at least 72 h in both negative and positive protein/PBS solutions at 37 degrees C. The current study is crucial for the translation of polyzwitterionic solution behavior to surfaces to exploit their diverse properties in the development of new, smart, and responsive coatings.
DOI10.1021/la2038558
Indexed BySCI
Language英语
WOS IDWOS:000298118500068
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73412
Collection中国科学院化学研究所
Corresponding AuthorJi, Xiangling
AffiliationChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Grad Sch, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Dong, Zhixin,Mao, Jun,Yang, Muquan,et al. Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions[J]. LANGMUIR,2011,27(24):15282-15291.
APA Dong, Zhixin,Mao, Jun,Yang, Muquan,Wang, Dapeng,Bo, Shuqin,&Ji, Xiangling.(2011).Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions.LANGMUIR,27(24),15282-15291.
MLA Dong, Zhixin,et al."Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions".LANGMUIR 27.24(2011):15282-15291.
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