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| Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases | |
| Liu, Kun-hui; Wu, Li-dan; Zou, Xiao-ran; Yang, Wen; Du, Qian; Su, Hong-mei | |
| 2011-10-01 | |
| Source Publication | CHINESE JOURNAL OF CHEMICAL PHYSICS
 |
| ISSN | 1674-0068 |
| Volume | 24Issue:5Pages:580-585 |
| Abstract | Pentachlorophenol, a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone (TCBQ) which can result in DNA damage. We have investigated the photochemical. reaction dynamics of TCBQ with two pyrimidine type nucleobases (thymine and uracil) upon UVA (355 nm) excitation using the technique of nanosecond time-resolved laser flash photolysis. It has been found that 355 nm excitation populates TCBQ molecules to their triplet state (3)TCBQ*, which are highly reactive towards thymine or uracil and undergo two parallel reactions, the hydrogen abstraction and electron transfer, leading to the observed photoproducts of TCBQH. and TCBQ.(-) in transient absorption spectra. The concomitantly produced nucleobase radicals and radical cations are expected to induce a series of oxidative or strand cleavage damage to DNA afterwards. By characterizing the photochemical hydrogen abstraction and electron transfer reactions, our results provide potentially important molecular reaction mechanisms for understanding the carcinogenic effects of pentachlorophenol and its metabolites TCBQ. |
| Keyword | Tetrachlorobenzoquinone Thymine Uracil Triplet State Hydrogen Abstraction Electron Transfer Laser Flash Photolysis |
| DOI | 10.1088/1674-0068/24/05/580-585 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000297139200012 |
| Publisher | CHINESE PHYSICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/73376 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Su, Hong-mei |
| Affiliation | Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,et al. Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases[J]. CHINESE JOURNAL OF CHEMICAL PHYSICS,2011,24(5):580-585. |
| APA | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,Yang, Wen,Du, Qian,&Su, Hong-mei.(2011).Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases.CHINESE JOURNAL OF CHEMICAL PHYSICS,24(5),580-585. |
| MLA | Liu, Kun-hui,et al."Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases".CHINESE JOURNAL OF CHEMICAL PHYSICS 24.5(2011):580-585. |
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