ICCAS OpenIR
Chiral Primary Amine Catalyzed Asymmetric Direct Cross-Aldol Reaction of Acetaldehyde
Hu, Shenshen; Zhang, Long; Li, Jiuyuan; Luo, Sanzhong; Cheng, Jin-Pei
2011-06-01
Source PublicationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN1434-193X
Issue18Pages:3347-3352
AbstractThe first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H4SiW12O40)(0.25) was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.
KeywordAldehydes Aldol Reactions Amines Asymmetric Catalysis Organocatalysis
DOI10.1002/ejoc.201100267
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000291583700010
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73364
Collection中国科学院化学研究所
Corresponding AuthorLuo, Sanzhong
AffiliationChinese Acad Sci, BNLMS, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu, Shenshen,Zhang, Long,Li, Jiuyuan,et al. Chiral Primary Amine Catalyzed Asymmetric Direct Cross-Aldol Reaction of Acetaldehyde[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2011(18):3347-3352.
APA Hu, Shenshen,Zhang, Long,Li, Jiuyuan,Luo, Sanzhong,&Cheng, Jin-Pei.(2011).Chiral Primary Amine Catalyzed Asymmetric Direct Cross-Aldol Reaction of Acetaldehyde.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(18),3347-3352.
MLA Hu, Shenshen,et al."Chiral Primary Amine Catalyzed Asymmetric Direct Cross-Aldol Reaction of Acetaldehyde".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .18(2011):3347-3352.
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