ICCAS OpenIR
Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug
Tang, Hongwei; Xing, Chengfen; Liu, Libing; Yang, Qiong; Wang, Shu
2011-05-23
Source PublicationSMALL
ISSN1613-6810
Volume7Issue:10Pages:1464-1470
AbstractA new amphiphilic conjugated polythiophene derivative (PT-Boc) is synthesized via Suzuki coupling reaction. The amphiphilic characteristic makes it form nanoaggregates in water, in which hydrophobic moieties come together to form the inner core. The polymer shows good photostability and no toxicity to human lung epithelial (A549) cells even at a high concentration (100 mu g mL(-1)). It therefore meets the crucial requirement for cellular imaging and other biological applications. The anticancer drug cisplatin is used as a model, and is linked to polythiophene to obtain a conjugate 'PT-Pt' by coordinated interactions between cisplatin and the amine groups of the polythiophene side chain. The PT-Pt can be used for monitoring the cellular distribution of cisplatin by fluorescence microscopy. The amphiphilic polythiophene provides a platform for fluorescent imaging of drugs and biological molecules in living cells.
DOI10.1002/smll.201002189
Indexed BySCI
Language英语
WOS IDWOS:000291087900021
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73272
Collection中国科学院化学研究所
Corresponding AuthorLiu, Libing
AffiliationChinese Acad Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Tang, Hongwei,Xing, Chengfen,Liu, Libing,et al. Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug[J]. SMALL,2011,7(10):1464-1470.
APA Tang, Hongwei,Xing, Chengfen,Liu, Libing,Yang, Qiong,&Wang, Shu.(2011).Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug.SMALL,7(10),1464-1470.
MLA Tang, Hongwei,et al."Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug".SMALL 7.10(2011):1464-1470.
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