ICCAS OpenIR
Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction
Yang Yong; Xia Tie; Zhang Wei; Fang XiaoHong
2011-04-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume56Issue:11Pages:1063-1067
AbstractFluorescence imaging of single molecules is becoming a powerful tool to examine biological processes at the molecular level. Using total internal reflection fluorescence microscopy (TIRFM), it has been possible to study the dynamic behavior of single molecules on living cell membranes. Herein, we briefly review the application of TIRFM-based single-molecule imaging in studies of membrane receptors involved in signal transduction. Furthermore, we discuss several examples of our own research on growth factor receptors, including TGF-beta receptors, HER2, and EGFR, and speculate possible applications of this technique to investigate other cellular events occurring on or near the plasma-membrane.
DOI10.1007/s11434-011-4415-1
Indexed BySCI
Language英语
WOS IDWOS:000289898600001
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73238
Collection中国科学院化学研究所
Corresponding AuthorFang XiaoHong
AffiliationChinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang Yong,Xia Tie,Zhang Wei,et al. Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction[J]. CHINESE SCIENCE BULLETIN,2011,56(11):1063-1067.
APA Yang Yong,Xia Tie,Zhang Wei,&Fang XiaoHong.(2011).Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction.CHINESE SCIENCE BULLETIN,56(11),1063-1067.
MLA Yang Yong,et al."Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction".CHINESE SCIENCE BULLETIN 56.11(2011):1063-1067.
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